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Article

CD40 promotion of amyloid beta production occurs via the NF-kappaB pathway.

The European journal of neuroscience - 1 Mar 2007

Ait-Ghezala Ghania, Volmar Claude-Henry, Frieling Jeremy, Paris Daniel, Tweed Miles, Bakshi Pancham, Mullan Michael

Abstract excerpt

The CD40 receptor is a member of the tumor necrosis factor (TNF) super-family of trans-membrane receptors. Interaction of CD40 with its ligand CD40L mediates a broad range of immune and inflammatory responses in the periphery and in the central nervous system. Recently it has been suggested that CD40/CD40L interaction is involved in amyloid precursor protein (APP) processing and Alzheimer's disease (AD)-like...

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Source

Identifiers

PMID: 17432959
DOI: 10.1111/j.1460-9568.2007.05424.x

Genes

APP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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