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Article

CD40 deficiency mitigates Alzheimer's disease pathology in transgenic mouse models

24 Feb 2006

Abstract excerpt

We have previously shown that transgenic mice carrying a mutant human APP but deficient in CD40L, display a decrease in astrocytosis and microgliosis associated with a lower amount of deposited Abeta. Furthermore, an anti-CD40L treatment causes a diminution of Abeta pathology in the brain and an improved performance in several cognitive tasks in the double transgenic PSAPP mouse model. Although these data suggest...

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PMID: 16504112
DOI: 10.1186/1742-2094-3-3

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