Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conformational change in the active center region of GST P1-1, due to binding of a synthetic conjugate of DXR with GSH, enhanced JNK-mediated apoptosis.

Apoptosis : an international journal on programmed cell death - 1 Jul 2007

Asakura Tadashi, Sasagawa Atsuko, Takeuchi Hitoshi, Shibata Shun-Ichi, Marushima Hideki, Mamori Satoshi, Ohkawa Kiyoshi

Abstract excerpt

Treatment of cells with a synthetic conjugate of DXR with GSH via glutaraldehyde (GSH-DXR) caused cytochrome c to be released from the mitochondria to the cytosol following potent activation of caspase-3 and -9 by typical DNA fragmentation. This apoptosis was regulated by the JNK-signaling pathway. In the present experiment, binding of GSH-DXR to GST P1-1 allosterically led to the disappearance of its enzyme...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Doxorubicin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Glutathione

Share to Glutathione S-Transferase pi

Share to JNK Mitogen-Activated Protein Kinases

Share to Recombinant Fusion Proteins

Share to Transfection

Source

Identifiers

PMID: 17431793
DOI: 10.1007/s10495-007-0053-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conformational change in the active center region of GST P1-1, due to binding of a synthetic conjugate of DXR with GSH, enhanced JNK-mediated apoptosis.PMID 17431793Read ↗

Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation.Semantic proximity Read ↗

Distinct mechanisms for the pro-apoptotic conformational transition and alkaline transition in cytochrome c.Semantic proximity Read ↗

Disulfide Bond-mediated multimerization of Ask1 and its reduction by thioredoxin-1 regulate H(2)O(2)-induced c-Jun NH(2)-terminal kinase activation and apoptosis.Semantic proximity Read ↗

C Terminus of DJ-1 Determines Its Homodimerization, Deglycation Activity and Suppression of FerroptosisSemantic proximity Read ↗

The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases.Semantic proximity Read ↗

Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1.Semantic proximity Read ↗

DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex.Semantic proximity Read ↗

Methylglyoxal induces apoptosis in Jurkat leukemia T cells by activating c-Jun N-terminal kinase.Semantic proximity Read ↗

Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain.Semantic proximity Read ↗

The conserved CXXC motif of hepatic stimulator substance is essential for its role in mitochondrial protection in H2O2-induced cell apoptosis.Semantic proximity Read ↗

Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner.Semantic proximity Read ↗

ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.