Article
The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases.
BMC cancer - 16 Aug 2019
Jezierska-Drutel Agnieszka, Attaran Shireen, Hopkins Barbara L, Skoko John J, Rosenzweig Steven A, Neumann Carola A
Abstract excerpt
BACKGROUND: Reactive oxygen species (ROS), including hydrogen peroxide, drive differentiation of normal fibroblasts into activated fibroblasts, which can generate high amounts of hydrogen peroxide themselves, thereby increasing oxidative stress in the microenvironment. This way, activated fibroblasts can transition into cancer-associated fibroblasts (CAFs). METHODS: Mammary fibroblasts from either female 8 weeks...
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