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Article

Cell polarity development and protein trafficking in hepatocytes lacking E-cadherin/beta-catenin-based adherens junctions.

Molecular biology of the cell - 1 Jun 2007

Théard Delphine, Steiner Magdalena, Kalicharan Dharamdajal, Hoekstra Dick, van Ijzendoorn Sven C D

Abstract excerpt

Using a mutant hepatocyte cell line in which E-cadherin and beta-catenin are completely depleted from the cell surface, and, consequently, fail to form adherens junctions, we have investigated adherens junction requirement for apical-basolateral polarity development and polarized membrane trafficking. It is shown that these hepatocytes retain the capacity to form functional tight junctions, develop full...

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Identifiers

PMID: 17429067
DOI: 10.1091/mbc.e06-11-1040
PMCID: PMC1877101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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