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Article

Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency

1 Feb 2022

Abstract excerpt

Background & Aims: The truncating mutations in tight junction protein 2 (TJP2) cause progressive cholestasis, liver failure, and hepatocyte carcinogenesis. Due to the lack of effective model systems, there are no targeted medications for the liver pathology with TJP2 deficiency. We leveraged the technologies of patient-specific induced pluripotent stem cells (iPSC) and CRISPR genome-editing, and we aim to...

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PMID: 35284810
DOI: 10.1016/j.jhepr.2022.100446

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