Article
Autoimmunity against laminins.
Clinical immunology (Orlando, Fla.) - 1 Sept 2016
Florea Florina, Koch Manuel, Hashimoto Takashi, Sitaru Cassian
Abstract excerpt
Laminins are ubiquitous constituents of the basement membranes with major architectural and functional role as supported by the fact that absence or mutations of laminins lead to either lethal or severely impairing phenotypes. Besides genetic defects, laminins are involved in a wide range of human diseases including cancer, infections, and inflammatory diseases, as well as autoimmune disorders. A growing body of...
Topics
- Animals
- Autoantibodies
- Autoantigens
- Autoimmunity
- Basement Membrane
- Humans
- Laminin
- Mutation
- Neoplasms
- Skin Diseases