Article
Directing endothelial differentiation of human embryonic stem cells via transduction with an adenoviral vector expressing the VEGF(165) gene.
The journal of gene medicine - 1 Jun 2007
Rufaihah Abdul Jalil, Haider Husnain Khawaja, Heng Boon Chin, Ye Lei, Toh Wei Seong, Tian Xian Feng, Lu Kai, Sim Eugene Kwang-Wei, Cao Tong
Abstract excerpt
Endothelial progenitors derived from human embryonic stem cells (hESCs) hold much promise in clinical therapy. Conventionally, lineage-specific differentiation of hESCs is achieved through supplementation of various cytokines and chemical factors within the culture milieu. Nevertheless, this is a highly inefficient approach that is often limited by poor replicability. An alternative is through genetic modulation...
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