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Vascular Endothelial Growth Factor 165 Gene Transfer Augments Circulating Endothelial Progenitor Cells in Human Subjects

23 Jun 2000

Abstract excerpt

Preclinical studies in animal models and early results of clinical trials in patients suggest that intramuscular injection of naked plasmid DNA encoding vascular endothelial growth factor (VEGF) can promote neovascularization of ischemic tissues. Such neovascularization has been attributed exclusively to sprout formation of endothelial cells derived from preexisting vessels. We investigated the hypothesis that...

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PMID: 10864908
DOI: 10.1161/01.res.86.12.1198

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