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Therapeutic Angiogenesis by Transplantation of Human Embryonic Stem Cell-Derived CD133 <sup>+</sup> Endothelial Progenitor Cells for Cardiac Repair

1 Mar 2010

Abstract excerpt

OBJECTIVE: This study aim to enhance endothelial differentiation of human embryonic stem cells (hESCs) by transduction of an adenovirus (Ad) vector expressing hVEGF(165) gene (Ad-hVEGF(165) ). Purified hESC-derived CD133(+) endothelial progenitors were transplanted into a rat myocardial infarct model to assess their ability to contribute to heart regeneration. METHODS: Optimal transduction efficiency with high...

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PMID: 20210583
DOI: 10.2217/rme.09.83

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