Highly diverse TCR delta chain repertoire in bovine tissues due to the use of up to four D segments per delta chain.

doi:10.1016/j.molimm.2007.02.003

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Article

Highly diverse TCR delta chain repertoire in bovine tissues due to the use of up to four D segments per delta chain.

Molecular immunology - 1 May 2007

Van Rhijn Ildiko, Spiering Rachel, Smits Mieke, van Blokland Marja T M, de Weger Roel, van Eden Willem, Rutten Victor P M G, Koets Ad P

Abstract excerpt

Tissue-specific distribution of gammadelta TCRs with limited TCR diversity is a common phenomenon in species with a low percentage of gammadelta T cells like humans and mice. We set out to investigate whether this is also the case in cattle (Bos taurus), a species with high percentages of gammadelta T cells. Using a method that was independent of variable (V) segment-specific primers, we generated 65 unique TCR...

Topics

Amino Acid Sequence
Animals
Cattle
DNA, Complementary
Genes, T-Cell Receptor delta
Genetic Variation
Receptors, Antigen, T-Cell, gamma-delta
Species Specificity
Tissue Distribution

Source

Open in PubMed

Identifiers

PMID: 17418895
DOI: 10.1016/j.molimm.2007.02.003

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