Article
Emergence of human immunodeficiency virus type 1 variants containing the Q151M complex in children receiving long-term antiretroviral chemotherapy.
Antiviral research - 1 Aug 2007
Harada Shigeyoshi, Hazra Rohan, Tamiya Sadahiro, Zeichner Steven L, Mitsuya Hiroaki
Abstract excerpt
We examined 28 children with HIV-1 infection who were not responding to existing antiviral regimens and were enrolled into clinical trials conducted at the National Cancer Institute to receive salvage therapy. In 3 of the 28 patients (10.7%), the Q151M complex amino acid substitutions were identified. The three patients had received nucleoside reverse transcriptase inhibitor (NRTI) monotherapy and/or combination...
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