Article
Slippage synthesis of simple sequence DNA.
Nucleic acids research - 25 Jan 1992
Schlötterer C, Tautz D
Abstract excerpt
The analysis of slippage synthesis of simple sequence DNA in vitro sheds some light on the question of how simple sequences arise in vivo. We show that it is possible to synthesize all types of repetitious di- and trinucleotide motifs starting from short primers and a polymerase in vitro. The rate of this synthesis depends on a sequence specific slippage rate, but is independent of the length of the fragments...
Topics
- Base Sequence
- DNA
- DNA Replication
- DNA-Directed DNA Polymerase
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid