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Article

Androgen Deprivation Increases p300 Expression in Prostate Cancer Cells

1 Apr 2007

Abstract excerpt

Standard therapy for nonorgan confined prostate cancer aims to block the production or action of androgens. Although initially successful, antiandrogen therapy eventually fails and androgen depletion independent (ADI) disease emerges. Remarkably, ADI prostate cancers still rely on a functional androgen receptor (AR). Aberrant expression of coregulatory proteins required for the formation of productive AR...

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PMID: 17409453
DOI: 10.1158/0008-5472.can-06-2836

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