Article
p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation.
The Journal of biological chemistry - 7 Jul 2000
Fu M, Wang C, Reutens A T, Wang J, Angeletti R H, Siconolfi-Baez L, Ogryzko V, Avantaggiati M L, Pestell R G
Abstract excerpt
The androgen receptor (AR) is a sequence-specific DNA-binding protein that plays a key role in prostate cancer cellular proliferation by dihydrotestosterone and the induction of secondary sexual characteristics. In this study we demonstrate that the AR can be modified by acetylation in vitro and in vivo. p300 and p300/cAMP-response element-binding protein acetylated the AR at a highly conserved lysine-rich motif...
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