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Article

Targeting abasic sites and single base bulges in DNA with metalloinsertors.

Journal of the American Chemical Society - 18 Jun 2008

Zeglis Brian M, Boland Jennifer A, Barton Jacqueline K

Abstract excerpt

The site-specific recognition of abasic sites and single base bulges in duplex DNA by sterically expansive rhodium metalloinsertors has been investigated. Through DNA photocleavage experiments, Rh(bpy)2(chrysi)3+ is shown to bind both abasic sites and single base bulges site-specifically and, upon irradiation, to cleave the backbone of the defect-containing DNA. Photocleavage titrations reveal that the metal...

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Identifiers

PMID: 18491905
DOI: 10.1021/ja801479y
PMCID: PMC2759749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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