Article
DNA mismatch detection by resonance energy transfer between ruthenium(II) and osmium(II) tris(2,2'-bipyridyl) chromophores.
Inorganic chemistry - 13 Jun 2005
Bichenkova Elena V, Yu Xuan, Bhadra Pranab, Heissigerova Helena, Pope Simon J A, Coe Benjamin J, Faulkner Stephen, Douglas Kenneth T
Abstract excerpt
Octahedral tris-chelate complexes [M(II)(bpy)(3)](2+) (M = Ru or Os, bpy = 2,2'-bipyridyl), covalently attached to the 3'- and 5'-phosphates of two oligonucleotides, are juxtaposed when hybridized contiguously to a fully complementary DNA target. Visible metal-to-ligand charge-transfer (MLCT) excitation of the [Ru(II)(bpy)(3)](2+) unit leads to resonance energy transfer to the MLCT state of the...
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