Article
Complete genetic linkage can subvert natural selection.
Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2007
Gerrish Philip J, Colato Alexandre, Perelson Alan S, Sniegowski Paul D
Abstract excerpt
The intricate adjustment of organisms to their environment demonstrates the effectiveness of natural selection. But Darwin himself recognized that certain biological features could limit this effectiveness, features that generally reduce the efficiency of natural selection or yield suboptimal adaptation. Genetic linkage is known to be one such feature, and here we show theoretically that it can introduce a more...
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