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Article

Linkage and the limits to natural selection.

Genetics - 1 Jun 1995

Barton N H

Abstract excerpt

The probability of fixation of a favorable mutation is reduced if selection at other loci causes inherited variation in fitness. A general method for calculating the fixation probability of an allele that can find itself in a variety of genetic backgrounds is applied to find the effect of substitutions, fluctuating polymorphisms, and deleterious mutations in a large population. With loose linkage, r, the effects...

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Identifiers

PMID: 7498757
DOI: 10.1093/genetics/140.2.821
PMCID: PMC1206655

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