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Article

Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein.

Journal of virology - 1 Jun 2007

Tan Ying-Xim, Tan Timothy H P, Lee Marvin J-R, Tham Puay-Yoke, Gunalan Vithiagaran, Druce Julian, Birch Chris, Catton Mike, Fu Nai Yang, Yu Victor C, Tan Yee-Joo

Abstract excerpt

The severe acute respiratory syndrome coronavirus (SARS-CoV) 7a protein, which is not expressed by other known coronaviruses, can induce apoptosis in various cell lines. In this study, we show that the overexpression of Bcl-XL, a prosurvival member of the Bcl-2 family, blocks 7a-induced apoptosis...

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Identifiers

PMID: 17428862
DOI: 10.1128/JVI.00090-07
PMCID: PMC1900074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17428862-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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