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Article

Identification of single-point mutations in mycobacterial 16S rRNA sequences by confocal single-molecule fluorescence spectroscopy.

Nucleic acids research - 26 Jul 2006

Marmé Nicole, Friedrich Achim, Müller Matthias, Nolte Oliver, Wolfrum Jürgen, Hoheisel Jörg D, Sauer Markus, Knemeyer Jens-Peter

Abstract excerpt

We demonstrate the specific identification of single nucleotide polymorphism (SNP) responsible for rifampicin resistance of Mycobacterium tuberculosis applying fluorescently labeled DNA-hairpin structures (smart probes) in combination with single-molecule fluorescence spectroscopy. Smart probes are singly labeled hairpin-shaped oligonucleotides bearing a fluorescent dye at the 5' end that is quenched by guanosine...

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Identifiers

PMID: 16870719
DOI: 10.1093/nar/gkl495
PMCID: PMC1540729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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