Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Engineering an endomorphin-2 gene for use in neuropathic pain therapy

29 Mar 2007

Abstract excerpt

Endomorphin-2 (EM-2) is a carboxy-amidated tetrapeptide that binds the mu-opioid receptor with high affinity and is analgesic in several animal models of pain. Endomorphin peptides have been isolated from bovine and human brain, but no DNA sequences corresponding to a potential preproendomorphin gene have been identified in human genome sequence databases. In this study we designed a tripartite synthetic gene to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve injury and regeneration
Share to Neuropeptides and Animal Physiology
Share to Pain Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17395375
DOI: 10.1016/j.pain.2007.02.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Engineering an endomorphin-2 gene for use in neuropathic pain therapyPMID 17395375Read ↗

dsAAV type 2-mediated gene transfer of MORS196A-EGFP into spinal cord as a pain management paradigm.Semantic proximity Read ↗

Herpes Vector–mediated Gene Transfer in the Treatment of Chronic PainSemantic proximity Read ↗

Structural optimization of pep7, a small peptide extracted from epimorphin, for effective induction of hair follicle anagen.Semantic proximity Read ↗

Foot‐and‐mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein.Semantic proximity Read ↗

Efficient Selection of DNA Aptamers with High Affinity and Specificity to GPCRs via Functional Extracellular VesiclesSemantic proximity Read ↗

Intrathecal delivery of a mutant micro-opioid receptor activated by naloxone as a possible antinociceptive paradigm.Semantic proximity Read ↗

Novel therapeutics based on recombinant botulinum neurotoxins to normalize the release of transmitters and pain mediators.Semantic proximity Read ↗

Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord.Semantic proximity Read ↗

Truncated μ-Opioid Receptors With 6 Transmembrane Domains Are Essential for Opioid AnalgesiaSemantic proximity Read ↗

Enteroviral Protease 2A Directly Cleaves Dystrophin and Is Inhibited by a Dystrophin-based Substrate AnalogueSemantic proximity Read ↗

Adeno-associated virus transfer of a gene encoding SNAP-25 resistant to botulinum toxin A attenuates neuromuscular paralysis associated with botulism.Semantic proximity Read ↗

Characterization of a computationally designed water-soluble human μ-opioid receptor variant using available structural information.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.