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Article

Fusion gene‐mediated truncation of <i>RUNX1</i> as a potential mechanism underlying disease progression in the 8p11 myeloproliferative syndrome

29 Mar 2007

Abstract excerpt

The 8p11 myeloproliferative syndrome (EMS) is a chronic myeloproliferative disorder molecularly characterized by fusion of various 5' partner genes to the 3' part of the fibroblast growth factor receptor 1 (FGFR1) gene at 8p, resulting in constitutive activation of the tyrosine kinase activity contained within FGFR1. EMS is associated with a high risk of transformation to acute myeloid leukemia (AML), but the...

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PMID: 17394134
DOI: 10.1002/gcc.20442

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