Article
8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes.
Genes, chromosomes & cancer - 1 Mar 2005
Belloni Elena, Trubia Maurizio, Gasparini Patrizia, Micucci Carla, Tapinassi Cinzia, Confalonieri Stefano, Nuciforo Paolo, Martino Bruno, Lo-Coco Francesco, Pelicci Pier Giuseppe, Di Fiore Pier Paolo
Abstract excerpt
8p11 myeloproliferative syndrome (EMS) is a clinical-pathologic entity characterized by rearrangements involving the FGFR1 gene, which encodes a receptor tyrosine kinase. These rearrangements invariably lead to aberrant fusion proteins in which the kinase activity is constitutively turned on, with resulting oncogenic properties. In this article, we describe a new translocation in EMS, t(7;8)(q34;p11), in which...
Topics
- Apoptosis
- Apoptosis Regulatory Proteins
- Base Sequence
- Carrier Proteins
- Chromosomes, Human, Pair 7
- Chromosomes, Human, Pair 8
- Female
- Genotype
- Humans
- Middle Aged
- Molecular Sequence Data
- Myeloproliferative Disorders