Article
Genetic strain differences in platelet aggregation and thrombus formation of laboratory rats.
Thrombosis and haemostasis - 1 Apr 2007
Sudo Toshiki, Ito Hideki, Hayashi Hideki, Nagamura Yoshie, Toga Kazuyuki, Yamada Yoshihisa
Abstract excerpt
Rats are employed to investigate the role of platelets in thrombus formation under flow conditions in vivo and to evaluate the pre-clinical potential of antiplatelet drugs. While Wistar and Sprague-Dawley (SD) strains are commonly used in thrombosis models, a number of rat strains have been established. Each strain possesses genetically unique characteristics such as hypertension, hyperglycemia or hyperlipidemia....
Topics
- Adenosine Diphosphate
- Animals
- Arteriovenous Shunt, Surgical
- Bleeding Time
- Blood Platelets
- Chlorides
- Collagen
- Disease Models, Animal
- Drug Evaluation, Preclinical
- Ferric Compounds
- Fibrinolytic Agents