Article
ABO blood group genotypes, plasma von Willebrand factor levels and loading of von Willebrand factor with A and B antigens.
Thrombosis and haemostasis - 1 Apr 2007
Morelli Vania M, de Visser Marieke C H, van Tilburg Nico H, Vos Hans L, Eikenboom Jeroen C J, Rosendaal Frits R, Bertina Rogier M
Abstract excerpt
ABO blood group is a genetic determinant of von Willebrand factor (VWF) levels. We investigated the effect of ABO genotypes on VWF and factor VIII (FVIII) levels and on the degree to which VWF is loaded with A- and B-antigens, expressed as normalized ratios, nA-ratio and nB-ratio, respectively, in the Leiden Thrombophilia Study, a large case-control study on venous thrombosis. We found that the ABO locus had an...
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