Article
The relationship between ABO histo-blood group, factor VIII and von Willebrand factor.
Transfusion medicine (Oxford, England) - 1 Aug 2001
O'Donnell J, Laffan M A
Abstract excerpt
ABO histo-blood group is a major determinant of plasma levels of factor VIII (FVIII) and von Willebrand factor (vWF). Blood group O individuals have significantly (approximately 25%) lower plasma levels of both glycoproteins. This association is of clinical significance. Low plasma levels of either FVIII or vWF have long been established as causes of excess bleeding. Conversely, there is accumulating evidence...
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