Article
Functional effects of the ABO locus polymorphism on plasma levels of von Willebrand factor, factor VIII, and activated partial thromboplastin time.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2000
Souto J C, Almasy L, Muñiz-Diaz E, Soria J M, Borrell M, Bayén L, Mateo J, Madoz P, Stone W, Blangero J, Fontcuberta J
Abstract excerpt
Lower levels of factor VIII and von Willebrand factor (vWF) have been reported in individuals with blood type O compared with individuals with other ABO blood types. However, this relationship has been demonstrated only by association studies and not by linkage studies. Also, it is not clear whether the ABO locus exerts a functional effect directly on these plasma factors or whether the ABO locus is in linkage...
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