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Article

A tick protein with a modified Kunitz fold inhibits human tryptase.

Journal of molecular biology - 11 May 2007

Paesen Guido C, Siebold Christian, Harlos Karl, Peacey Mick F, Nuttall Patricia A, Stuart David I

Abstract excerpt

TdPI, a tick salivary gland product related to Kunitz/BPTI proteins is a potent inhibitor of human beta-tryptase. Kinetic assays suggest that three of the four catalytic sites of tryptase are blocked by TdPI, and that the inhibition of one of these involves a peptide flanking the Kunitz head. In the course of the inhibition, tryptase cleaves TdPI at several positions. Crystal structures of the TdPI head, on its...

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Identifiers

PMID: 17391695
DOI: 10.1016/j.jmb.2007.03.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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