Article
Allelic polymorphism in the Plasmodium vivax dihydrofolate reductase gene among Indian field isolates.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Mar 2007
Prajapati S K, Joshi H, Valecha N, Reetha A M, Eapen A, Kumar A, Das M K, Yadav R S, Rizvi M A, Dash A P
Abstract excerpt
In total, 129 Plasmodium vivax isolates from different geographical areas in India were analysed for point mutations in the P. vivax dihydrofolate reductase gene that were associated with pyrimethamine resistance. A gradual increase in the frequency of mutant genotypes was observed from north to south (p <0.0001). In the northern region (Delhi, Panna and Nadiad), the wild-type genotype was most prevalent, while...
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