Article
Molecular epidemiology of Plasmodium vivax anti-folate resistance in India.
Malaria journal - 24 Apr 2011
Prajapati Surendra K, Joshi Hema, Dev Vas, Dua Virendra K
Abstract excerpt
BACKGROUND: Sulphadoxine and pyrimethamine are anti-folate drugs that show synergistic anti-malarial effect. Point mutations in dihydrofolate reductase (dhfr) and dihydropteorate synthatase (dhps) cause anti-folate drug resistance phenotype in human malaria parasites. This study presents pattern of point mutations in dhfr/dhps genes among Indian sub-continent. METHODS: Microscopically diagnosed one hundred...
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