Article
Engineering proteinase K using machine learning and synthetic genes.
BMC biotechnology - 26 Mar 2007
Liao Jun, Warmuth Manfred K, Govindarajan Sridhar, Ness Jon E, Wang Rebecca P, Gustafsson Claes, Minshull Jeremy
Abstract excerpt
BACKGROUND: Altering a protein's function by changing its sequence allows natural proteins to be converted into useful molecular tools. Current protein engineering methods are limited by a lack of high throughput physical or computational tests that can accurately predict protein activity under conditions relevant to its final application. Here we describe a new synthetic biology approach to protein engineering...
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