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Article

Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7.

Molecular pharmacology - 1 Jun 2007

Kapur Ankur, Hurst Dow P, Fleischer Daniel, Whitnell Rob, Thakur Ganesh A, Makriyannis Alexandros, Reggio Patricia H, Abood Mary E

Abstract excerpt

Ligands of structurally diverse natures are able to bind at the CB(1) cannabinoid receptor, suggesting the existence of multiple binding sites on the receptor. Modeling studies have implicated Ser2.60(173) and Ser7.39(383) as possible interaction site(s) for CB(1) agonists. To test the importance of these residues for receptor recognition, recombinant human CB(1) receptors, stably expressed in human embryonic...

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Identifiers

PMID: 17384224
DOI: 10.1124/mol.107.034645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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