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Article

Quantitating tissue specificity of human genes to facilitate biomarker discovery.

Bioinformatics (Oxford, England) - 1 Jun 2007

Vasmatzis George, Klee Eric W, Kube Dagmar M, Therneau Terry M, Kosari Farhad

Abstract excerpt

We describe a method to identify candidate cancer biomarkers by analyzing numeric approximations of tissue specificity of human genes. These approximations were calculated by analyzing predicted tissue expression distributions of genes derived from mapping expressed sequence tags (ESTs) to the human genome sequence using a binary indexing algorithm. Tissue-specificity values facilitated high-throughput analysis...

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Identifiers

PMID: 17384019
DOI: 10.1093/bioinformatics/btm102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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