Article
Differential effects of apolipoprotein E3 and E4 on markers of oxidative status in macrophages.
The British journal of nutrition - 1 May 2007
Jofre-Monseny Laia, de Pascual-Teresa Sonia, Plonka Eva, Huebbe Patricia, Boesch-Saadatmandi Christine, Minihane Anne-Marie, Rimbach Gerald
Abstract excerpt
ApoE is secreted by macrophages at the lesion site of the atherosclerotic plaque, where it is thought to play a protective role against atherosclerosis independently of its effects on lipid metabolism. Of the three common isoforms for apoE, apoE4 is associated with higher risk of cardiovascular disease (CVD). In vitro studies have shown that recombinant apoE may act as an antioxidant in an isoform-dependent...
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