Article
The role of CRISPR-Cas systems in virulence of pathogenic bacteria.
Microbiology and molecular biology reviews : MMBR - 1 Mar 2014
Louwen Rogier, Staals Raymond H J, Endtz Hubert P, van Baarlen Peter, van der Oost John
Abstract excerpt
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genes are present in many bacterial and archaeal genomes. Since the discovery of the typical CRISPR loci in the 1980s, well before their physiological role was revealed, their variable sequences have been used as a complementary typing tool in diagnostic, epidemiologic, and evolutionary analyses of prokaryotic strains....
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