Article
The role of Wilms' tumor gene peptide-specific cytotoxic T lymphocytes in immunologic selection of a paroxysmal nocturnal hemoglobinuria clone.
Experimental hematology - 1 Apr 2007
Ikeda Kazuhiko, Shichishima Tsutomu, Yasukawa Masaki, Nakamura-Shichishima Akiko, Noji Hideyoshi, Akutsu Kazuko, Osumi Kazuoki, Maruyama Yukio
Abstract excerpt
OBJECTIVE: To clarify an expansion mechanism of a paroxysmal nocturnal hemoglobinuria (PNH) clone with the Wilms' tumor gene (WT1). MATERIALS AND METHODS: In PNH patients with the HLA-A*2402 allele, frequencies of peripheral blood (PB) WT1 peptide-specific and HLA-A*2402-restricted CD8+ cells and...
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