Article

Spontaneous high clonal expansion of Wilms’ tumor gene 1 (WT1)-specific cytotoxic T-lymphocytes in patients with WT1-expressing solid tumor

2024-06-13

Abstract excerpt

<title>Abstract</title> <p>Wilms’ tumor protein 1 (WT1)-targeted immunotherapy has been used in patients with leukemia and solid tumors. However, the spontaneous WT1-specific immune response before WT1 peptide vaccination in patients with WT1-expressing tumors (PTs) remains unclear. Therefore, we investigated whether WT1-specific cytotoxic CD8<sup>+</sup> T-lymphocytes (CTLs) are clonally expanded in the peripher...

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Literature Corpus work: e04078c7-cb1d-550f-9d86-4897ad508ea1
DOI: 10.21203/rs.3.rs-4490607/v1

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