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Article

D- and L-2',3'-didehydro-2',3'-dideoxy-3'-fluoro-carbocyclic nucleosides: synthesis, anti-HIV activity and mechanism of resistance.

Journal of medicinal chemistry - 19 Apr 2007

Wang Jianing, Jin Yunho, Rapp Kimberly L, Schinazi Raymond F, Chu Chung K

Abstract excerpt

Introducing 2'-fluoro substitution on the 2',3'-double bond in carbocyclic nucleosides has provided biologically interesting compounds with potent anti-HIV activity. As an extension of our previous works in the discovery of anti-HIV agents, D- and L-2',3'-unsaturated 3'-fluoro carbocyclic nucleosides were synthesized and evaluated against HIV-1 in human peripheral blood mononuclear (PBM) cells. Among the...

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Identifiers

PMID: 17373782
DOI: 10.1021/jm061304k
PMCID: PMC2533426

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Source receipt: pubmed, retrieved 7 Sept 2026.

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