Article
2'-β-Methylselenyl nucleos(t)ide analogs as reverse transcriptase inhibitors against diverse HIV mutants.
Bioorganic & medicinal chemistry - 1 Aug 2024
Yoshida Yuki, Niimi Yushi, Fushihara Daichi, Katakura Hideo, Fukui Ryusuke, Murase Hirotaka, Tomoike Fumiaki, Hashiya Fumitaka, Murakami Tsutomu, Kodama Eiichi N, Suzuki Tetsuro, Yasukawa Kiyoshi, Kimura Yasuaki, Abe Hiroshi
Abstract excerpt
Nucleoside reverse transcriptase inhibitors (NRTIs) have been extensively studied as drugs targeting HIV RT. However, the practice or use of approved NRTIs lacking the 3'-hydroxy group often promotes frequent HIV mutations and generates drug-resistance. Here, we describe a novel NRTI with 2'-β-methylselenyl modification. We found that this modification inhibited the DNA elongation reaction by HIV-1 RT despite...
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