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Article

Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy.

Molecules (Basel, Switzerland) - 26 Feb 2020

Lei Yuan, Han Sheng, Yang Yang, Pannecouque Christophe, De Clercq Erik, Zhuang Chunlin, Chen Fen-Er

Abstract excerpt

The key problems of human immunodeficiency virus (HIV) therapy are the rapid emergence of drug-resistant mutant strains and significant cumulative drug toxicities. Therefore, there is an urgent demand for new anti-HIV agents with low toxicity and broad-spectrum antiviral potency. A series of biphenyl-substituted diarylpyrimidines with a cyanomethyl linker were designed using a molecular hybridization strategy....

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Identifiers

PMID: 32111013
DOI: 10.3390/molecules25051050
PMCID: PMC7179183

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