Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution

Abstract excerpt

Post-translational modification of proteins by ubiquitin or ubiquitin-like polypeptides such as Nedd8 controls cellular functions including protein degradation, the cell cycle and transcription. Here we have used an activity-based chemical probe that covalently labels ubiquitin hydrolases. We identify four such enzymes from Toxoplasma gondii by mass spectrometry. The homologue of mammalian UCHL3 was cloned from...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autophagy in Disease and Therapy
• Share to Toxoplasma gondii Research Studies
• Share to Ubiquitin and proteasome pathways