Article

An evolutionary approach to systematic discovery of novel deubiquitinases, applied to Legionella

2020-07-01

Abstract excerpt

Deubiquitinating enzymes (DUBs) are important regulators of the posttranslational protein ubiquitination system. Mammalian genomes encode about hundred different DUBs, which can be grouped into seven different classes. Members of other DUB classes are found in pathogenic bacteria, which use them to target the host defense. By combining bioinformatical and experimental approaches, we address the question if the kno...

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Literature Corpus work: 9e98fe81-28fa-5767-ab18-1197ae59dc98
DOI: 10.1101/2020.07.01.182683

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