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Article

Characterization and comparison of the red blood cell membrane damage in severe human alpha- and beta-thalassemia

15 Feb 1992

Abstract excerpt

The aim of the present work was to understand the pathophysiology of the severe human thalassemias as represented by beta-thalassemia intermedia and hemoglobin (Hb) H (alpha-thalassemia) disease. We have previously shown that the material properties of the red blood cell (RBC) and its membrane differ in severe alpha- and beta-thalassemia, and we now show that this difference is probably caused by accumulation of...

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Identifiers

PMID: 1737089
DOI: 10.1182/blood.v79.4.1058.1058

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