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Article

Membrane Phospholipid Asymmetry in Human Thalassemia

15 Apr 1998

Abstract excerpt

Phospholipid asymmetry in the red blood cell (RBC) lipid bilayer is well maintained during the life of the cell, with phosphatidylserine (PS) virtually exclusively located in the inner monolayer. Loss of phospholipid asymmetry, and consequently exposure of PS, is thought to play an important role in red cell pathology. The anemia in the human thalassemias is caused by a combination of ineffective erythropoiesis...

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Identifiers

PMID: 9531618
DOI: 10.1182/blood.v91.8.3044.3044_3044_3051

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