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Article

The decay accelerating factor mutation I197V found in hemolytic uraemic syndrome does not impair complement regulation.

Molecular immunology - 1 May 2007

Kavanagh D, Burgess R, Spitzer D, Richards A, Diaz-Torres M L, Goodship J A, Hourcade D E, Atkinson J P, Goodship T H J

Abstract excerpt

Hemolytic uremic syndrome is the clinical triad of thrombocytopenia, microangiopathic hemolytic anaemia and acute renal failure. Cases not associated with a preceding Shiga-like toxin producing Escherichia coli are described as atypical HUS (aHUS). Approximately 50% of patients with aHUS have mutations in one of three complement regulatory proteins, Factor H (CFH), membrane cofactor protein (MCP;CD46) or factor I...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17368771
DOI: 10.1016/j.molimm.2007.01.036

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The decay accelerating factor mutation I197V found in hemolytic uraemic syndrome does not impair complement regulation.PMID 17368771Read ↗

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