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Article

Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome.

Blood - 15 Aug 2006

Caprioli Jessica, Noris Marina, Brioschi Simona, Pianetti Gaia, Castelletti Federica, Bettinaglio Paola, Mele Caterina, Bresin Elena, Cassis Linda, Gamba Sara, Porrati Francesca, Bucchioni Sara, Monteferrante Giuseppe, Fang Celia J, Liszewski M K, Kavanagh David, Atkinson John P, Remuzzi Giuseppe

Abstract excerpt

Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy with manifestations of hemolytic anemia, thrombocytopenia, and renal impairment. Genetic studies have shown that mutations in complement regulatory proteins predispose to non-Shiga toxin-associated HUS (non-Stx-HUS). We undertook genetic analysis on membrane cofactor protein (MCP), complement factor H (CFH), and factor I (IF) in 156 patients with...

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Identifiers

PMID: 16621965
DOI: 10.1182/blood-2005-10-007252
PMCID: PMC1895874

Genes

CFH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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