Article
Common genetic variation in the ATP-binding cassette transporter A1, plasma lipids, and risk of coronary heart disease.
Atherosclerosis - 1 Nov 2007
Jensen Majken K, Pai Jennifer K, Mukamal Kenneth J, Overvad Kim, Rimm Eric B
Abstract excerpt
The ATP-binding cassette transporter A-1 (ABCA1) regulates cholesterol efflux from cells and is involved in high-density lipoprotein (HDL) metabolism and atherogenesis. We investigated whether common ABCA1 variants, previously reported to have phenotypic effects in humans, were associated with plasma lipids and CHD in a prospective study of coronary heart disease (CHD) in healthy women. Three polymorphisms in the...
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