Article
Genotype-phenotype correlations as a guide in the management of familial adenomatous polyposis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Mar 2007
Nieuwenhuis Mary H, Mathus-Vliegen Lisbeth M, Slors Frederik J, Griffioen Gerrit, Nagengast Fokko M, Schouten Wim R, Kleibeuker Jan H, Vasen Hans F A
Abstract excerpt
BACKGROUND & AIMS: The options for prevention of colorectal cancer in familial adenomatous polyposis are either a colectomy with ileorectal anastomosis (IRA) or a total proctocolectomy with ileal pouch-anal anastomosis (IPAA). Rectal cancer risk is eliminated by IPAA, but complication rate is higher than in IRA. Mutation analysis might predict severity of polyposis and be helpful in the surgical decision....
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