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Article

Genotype predicting phenotype in familial adenomatous polyposis: a practical application to the choice of surgery.

Diseases of the colon and rectum - 1 Jul 2009

Nieuwenhuis Marry H, Bülow Steffen, Björk Jan, Järvinen Heikki J, Bülow Charlotte, Bisgaard Marie Luise, Vasen Hans F A

Abstract excerpt

PURPOSE: Genetic information may help preoperatively select patients with familial adenomatous polyposis for either colectomy with ileorectal anastomosis or proctocolectomy with ileal pouch-anal anastomosis. Although complicated, the latter procedure has a low long-term risk of rectal cancer. METHODS: Data were obtained from four national polyposis registries. On the basis of previously described...

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PMID: 19571702
DOI: 10.1007/DCR.0b013e3181a0d33b

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